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- W2360848881 abstract "AIM To establish a LC-MS/MS method for the determination of venlafaxine and O-desmethylvenlafaxine in human plasma.METHODS After addition of venlafaxine-D6(internal standard,IS)and O-desmethylvenlafaxine-D6(IS)combination,the analyte was processed by protein precipitation.The chromatographic separation was performed on CAPCELL PAK C18 MGⅢ(100 mm × 2.0 mm,5 μm)column with a mobile phase of 0.3% formic acid water-0.3% formic acid acetonitrile(78 ∶ 22,V/V)at a flow rate of 0.3 mL·min-1.The protonated ions of analytes were detected in positive ionization by multiple reaction monitoring mode(MRM).The mass transition pairs of m/z 278→58,m/z 264→58 and m/z 284→58,m/z 270→58 were used to detect venlafaxine,venlafaxine-D6 and O-desmethylvenlafaxine,O-desmethylvenlafaxine-D6,respectively.RESULTS The linear concentration range for venlafaxine and O-desmethylvenlafaxine were both 2-1 000 μg·L-1.The limit of quantitation for both was 2 μg·L-1.The extraction recovery was 90.14%-97.33%.Within-batch RSD and between-batch RSD were less than 8%.CONCLUSION This method is simple,specific and sensitive,and suitable for determination studies of venlafaxine and O-desmethylvenlafaxine in human plasma." @default.
- W2360848881 created "2016-06-24" @default.
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- W2360848881 date "2011-01-01" @default.
- W2360848881 modified "2023-09-22" @default.
- W2360848881 title "Determination of venlafaxine and its metabolite O-desmethylvenlafaxine in human plasma by LC-MS/MS method" @default.
- W2360848881 hasPublicationYear "2011" @default.
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