FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2360862007> ?p ?o ?g. }

• W2360862007 abstract "Dendritic cells (DC) sense infection in their microenvironment and undergo a dynamic process of changes in phagocytic capacity, morphology and migratory activity in order to induce optimum T cell immunity. The acquisition of these properties is termed maturation. In this study, key selected aspects of this DC maturation process have been explored. One aspect of DC maturation is the signalling pathways that DC use to respond to micro-environmental signals. DC respond to conserved microbial structures in their micro-environment via pattern recognition receptors including Toll-like receptors (TLRs). Generally it is thought that this leads to activation of the mitogen-activated protein kinase (MAPK) pathways, p38, ERK, and JNK. JNK and p38 MAPK are also activated by reactive oxygen species, including hydrogen peroxide (H202), known to be present in the inflammatory DC milieu. Therefore the ability of H2O 2 to stimulate DC, or modulate their response to TLR ligands such as lipopolysaccharide (LPS) was examined. Activation of JNK, associated with inhibition of tyrosine phosphatases, is linked to induction of DC apoptosis. JNK inhibition partially protected the DC from the pro-apoptotic effects of H2O2. Furthermore, H2O2 and LPS synergise in inducing JNK activation, and DC apoptosis. These studies suggest that excessive DC maturation, which may induce pathogenic T cell activation may be limited by DC apoptosis. The second section of the thesis explores the mechanisms leading to MAPK activation upon TLR ligation. Biochemical studies demonstrated that mixed lineage kinase 3 (MLK3), a kinase not previously implicated in DC maturation, was phosphorylated upon TLR3 and 4, but not TLR2 ligation. Studies using a selective MLK inhibitor supported a role for the mixed lineage kinase (MLK) family of MAPK kinase kinase (MAP3K) proteins in regulation of DC signalling, phenotype and cytokine secretion, in response to TLR3 and 4, but not TLR2 ligation. Selective activation of MAP3K may therefore contribute to the heterogeneity and flexibility of DC/pathogen interaction. A further feature of the DC sensory role is antigen uptake, but the relationship between morphology and phagocytic capacity has not been defined. Therefore a simple and flexible assay to examine this relationship was developed. DC with long dendritic processes were less efficient at antigen internalisation than round DCs." @default.
• W2360862007 created "2016-06-24" @default.
• W2360862007 creator A5013921278 @default.
• W2360862007 date "2005-01-01" @default.
• W2360862007 modified "2023-09-24" @default.
• W2360862007 title "Mitogen-activated protein kinases in dendritic cell maturation and death" @default.
• W2360862007 hasPublicationYear "2005" @default.
• W2360862007 type Work @default.
• W2360862007 sameAs 2360862007 @default.
• W2360862007 citedByCount "0" @default.
• W2360862007 crossrefType "dissertation" @default.
• W2360862007 hasAuthorship W2360862007A5013921278 @default.
• W2360862007 hasConcept C132149769 @default.
• W2360862007 hasConcept C184235292 @default.
• W2360862007 hasConcept C185592680 @default.
• W2360862007 hasConcept C51551487 @default.
• W2360862007 hasConcept C57074206 @default.
• W2360862007 hasConcept C62478195 @default.
• W2360862007 hasConcept C86803240 @default.
• W2360862007 hasConcept C95444343 @default.
• W2360862007 hasConcept C97029542 @default.
• W2360862007 hasConceptScore W2360862007C132149769 @default.
• W2360862007 hasConceptScore W2360862007C184235292 @default.
• W2360862007 hasConceptScore W2360862007C185592680 @default.
• W2360862007 hasConceptScore W2360862007C51551487 @default.
• W2360862007 hasConceptScore W2360862007C57074206 @default.
• W2360862007 hasConceptScore W2360862007C62478195 @default.
• W2360862007 hasConceptScore W2360862007C86803240 @default.
• W2360862007 hasConceptScore W2360862007C95444343 @default.
• W2360862007 hasConceptScore W2360862007C97029542 @default.
• W2360862007 hasLocation W23608620071 @default.
• W2360862007 hasOpenAccess W2360862007 @default.
• W2360862007 hasPrimaryLocation W23608620071 @default.
• W2360862007 hasRelatedWork W1828479613 @default.
• W2360862007 hasRelatedWork W1843530564 @default.
• W2360862007 hasRelatedWork W2010563826 @default.
• W2360862007 hasRelatedWork W2030084232 @default.
• W2360862007 hasRelatedWork W2044471952 @default.
• W2360862007 hasRelatedWork W2047046033 @default.
• W2360862007 hasRelatedWork W2050226159 @default.
• W2360862007 hasRelatedWork W2061972001 @default.
• W2360862007 hasRelatedWork W2064650401 @default.
• W2360862007 hasRelatedWork W2079107138 @default.
• W2360862007 hasRelatedWork W2113553995 @default.
• W2360862007 hasRelatedWork W2114829829 @default.
• W2360862007 hasRelatedWork W2124884323 @default.
• W2360862007 hasRelatedWork W2141575322 @default.
• W2360862007 hasRelatedWork W2146825863 @default.
• W2360862007 hasRelatedWork W2163572044 @default.
• W2360862007 hasRelatedWork W2477691052 @default.
• W2360862007 hasRelatedWork W2805368110 @default.
• W2360862007 hasRelatedWork W2959833447 @default.
• W2360862007 hasRelatedWork W825784418 @default.
• W2360862007 isParatext "false" @default.
• W2360862007 isRetracted "false" @default.
• W2360862007 magId "2360862007" @default.
• W2360862007 workType "dissertation" @default.