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- W2360864250 abstract "Objective To evaluate the effect of tiotropium on exacerbations and airflow in patients with COPD.Method Patients with COPD were recruited from outpatient of Guangzhou First Municipal People's Hospital.Eligible patients were randomised 1:1 to receive either tiotropium 18 mg(n=87) once daily or placebo(n=86) for 48 weeks.Detailed information on exacerbations of COPD,hospital admissions due to a COPD exacerbation and concomitant medications were collected at randomisation(day 1) as well as after 6,12,24,36 and 48 weeks of treatment.Result 173 patients with COPD were recruited.The mean ± SD number of exacerbations during the past year was 2.32 ± 1.36,the mean weekly morning peak expiratory flow(PEF) was(225.7 ± 94.3) L/min and the mean forced expiratory volume in one second(FEV1) was(1.36 ± 0.76) L.Tiotropium significantly delayed the time to first exacerbation by 91 days,reduced the proportion of patients experiencing more than one exacerbation by 17%,and decreased the number of exacerbations by 34% and exacerbation days by 36% versus placebo.Mean weekly morning PEF improved significantly with tiotropium versus placebo from week 1 until the end of the study.At the end of the study,tiotropium significantly improved trough(pre-dose) FEV1,forced vital capacity,slow vital capacity and inspiratory capacity versus placebo.Conclusion Tiotropium reduced exacerbations and improved airflow over one year in patients with chronic obstructive pulmonary disease." @default.
- W2360864250 created "2016-06-24" @default.
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- W2360864250 date "2011-01-01" @default.
- W2360864250 modified "2023-09-24" @default.
- W2360864250 title "The Role of Tiotropium on Exacerbations and Airflow in Patients with COPD" @default.
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