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- W2360864781 abstract "AIM: To observe the effect of endothelin receptor antagonist(BQ123) on calcification in rat vascular smooth muscle cells(VSMCs) in vitro.METHODS: Calcification of cultured rat VSMCs was produced by incubation with β-glycerophosphate.Calcium content,Ca2+ deposition and alkaline phosphatase activity were analyzed to estimate the extent of calcification.The DNA synthesis was detected by -TdR and -Leu incorporation.Osteopontin(OPN) mRNA was measured by competitive quantitative RT-PCR.Content of ET was measured by radioimmunoassay(RIA).RESULTS: The results showed that compared with the control,the content of calcium,[45Ca2+] uptake and alkaline phosphatases activities in calcified VSMCs increased by 118%,174% and 7-fold(all P0.01),respectively.The expression of OPN mRNA in calcified VSMCs was up-regulated by 86%(P0.01).The calcified VSMCs grew rapidly,in which -TdR and -Leu were elevated by 71% and 35%.The content of ET in calcified VSMCs medium was increased by 35% as compared with control.Furthermore,calcified VSMCs plus BQ123 groups obviously relieved degree of calcification,of which calcium content,Ca2+ deposition and alkaline phosphatase activities were 33%,37%,40% lower than those in calcified VSMCs(P0.01),respectively.The expression of OPN mRNA was down-regulated by 25%(P0.01) and significantly inhibited VSMCs proliferation.CONCLUSION: BQ123 reduces VSMCs calcification,suggesting that ET promotes calcification in VSMCs mainly by ET/ ETA receptor pathway." @default.
- W2360864781 created "2016-06-24" @default.
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- W2360864781 date "2008-01-01" @default.
- W2360864781 modified "2023-09-25" @default.
- W2360864781 title "Endothelin receptor antagonist BQ123 inhibits calcification in vascular smooth muscle cells induced by β-glycerophosphate" @default.
- W2360864781 hasPublicationYear "2008" @default.
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