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- W2360873225 abstract "Aim To explore the antidepressant-like effect and mechanism of agmatine in chronically stressed mice.Methods The antidepressant-like effect of agmatine was evaluated by using the chronic stress model in mice. Western blot was used for measuring the expression of brain-derived neurotrophic factors (BDNF),extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB).Results The open-field exploratory behavior and locomotor activity were significantly decreased,while the latency to feed in novelty-suppressed feeding tests increased in chronically stressed mice. Co-administration of agmatine(10,20mg·kg-1,ig)or imipramine(10mg·kg-1,ig) reversed those effects. Furthermore,chronic stress also down-regulated the level of BDNF,pERK,pCREB protein expression in hippocampus,while co-administration of agmatine or imipramine blocked such effect.Conclusion Agmatine produced antidepressant-like effect in the chronically stressed model in mice,which may be closely mediated by up-regulation of BDNF,pERK,pCREB. So the antidepressant-like effect of agmatine may be related to the neurotrophic signaling cascade." @default.
- W2360873225 created "2016-06-24" @default.
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- W2360873225 date "2008-01-01" @default.
- W2360873225 modified "2023-09-25" @default.
- W2360873225 title "Evaluation of the Antidepressant-like Effect of Agmatine in Chronically Stressed Mice" @default.
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