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- W2360876141 abstract "AIM:To examine the pathway related to the IL-1β- induced activation of mitogen-activated protein(MAP) kinases in cat esophageal smooth muscle cells. METHODS:Culture of the esophageal smooth muscle cells from cat was prepared.Specific inhibitors were treated before applying the IL-1β.Western blot analysis was performed to detect the expressions of COX,iNOS and MAP kinases. RESULTS:In the primary cultured cells,although IL-1β failed to upregulate the COX and iNOS levels,the levels of the phosphorylated forms of p44/42 MAP kinase and p38 MAP kinase increased in both concentration-and time-dependent manner,of which the level of activation reached a maximum within 3 and 18 h,respectively. The pertussis toxin reduced the level of p44/42 MAP kinase phosphorylation.Tyrphostin 51 and genistein also inhibited this activation.Neomycin decreased the density of the p44/42 MAP kinase band to the basal level. Phosphokinase C(PKC)was found to play a mediating role in the IL-1β-induced p44/42 MAP kinase activity. In contrast,the activation of p38 MAP kinase was inhibited only by a pretreatment with forskolin,and was unaffected by the other compounds. CONCLUSION:Based on these results,IL-1β-induced p44/42 MAP kinase activation is mediated by the Gi protein,tyrosine kinase,phospholipase C(PLC)and PKC.The pathway for p38 MAP kinase phosphorylation is different from that of p44/42 MAP kinase,suggesting that it piays a different role in the cellular response to IL- 1β." @default.
- W2360876141 created "2016-06-24" @default.
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- W2360876141 date "2006-01-01" @default.
- W2360876141 modified "2023-09-23" @default.
- W2360876141 title "IL-1β activates p44/42 and p38 mitogen-activated protein kinases via different pathways in cat esophageal smooth muscle cells" @default.
- W2360876141 hasPublicationYear "2006" @default.
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