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- W2360876883 abstract "Objective: To investigate the prognostic value and clinicopathological correlation of tumor Rb, p16 and cycinD1 protein expression in patients with oral squamous cell carcinoma (OSCC). Methods: Immunohistochemical analysis was performed to examine tumor Rb, p16 and cycinD1 proteins level in 37 cases of OSCC, and Fisher' exact test was used to analyze the results with relevant clinicopathological factors. Results: Positive expression of Rb, cyclinD1 and p16 protein were observed in 28/37 (76%),18/37(49%) and 21/37(57%) cases of OSCC, respectively. An inverse correlation was found between p16 and Rb protein level expression statistically ( P =0.02); cyclinD1 over-expression was associated with tumor size ( P =0.02) and lymph node metastases ( P =0.01); Diminished protein level of p16 was detected in the elderly group (over 60 years) as compared with the younger group (less than 60 years) ( P =0.02). Conclusions: 1) The possible interaction between Rb and p16 plays a role in OSCC tumorigenesis, 2) Loss of the p16 protein expression may be the early event in the OSCC development, 3) Over-expression of cyclinD1 might be more correlated to tumor progression than to tumor initiation and critical in tumor cell proliferation and metastasis to lymph nodes. Furthermore, cyclinD1 may be a potential marker clinically as a predictor of lymph node metastases and guide therapeutic strategies in OSCC." @default.
- W2360876883 created "2016-06-24" @default.
- W2360876883 creator A5017853577 @default.
- W2360876883 date "2005-01-01" @default.
- W2360876883 modified "2023-09-23" @default.
- W2360876883 title "Immunohistochemical Expression of Rb/cyclinD1/p16 Pathway Proteins in Oral Squamous Cell Carcinoma: Correlation with Clinicopathological Features." @default.
- W2360876883 hasPublicationYear "2005" @default.
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