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- W2360876898 abstract "Objective: To investigate the role of cancer testis antigen CT45-5 in DNA damage response by using CT45-5-siRNA.Methods: After CT45-5 gene was knocked down by siRNA and treatment with camptothecin(CPT) or etoposide(Et) or ionizing radiation(IR),the stable cell lines 3-18,overexpressing human fragile histi dine triad(Fhit),were harvested at different time,cell survival fractions and cell cycles were tested by using MTT assay or flow cytometry.Results: The cells overxpressing Fhit by knocking down CT45-5 gene showed stronger G2 checkpoint response to IR and more resistant to CPT and Et-induced killing than control cells following DNA damage inducer.Conclusion: CT45-5 may involve in the DNA demage response by Fhit-dependent pathway." @default.
- W2360876898 created "2016-06-24" @default.
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- W2360876898 date "2013-01-01" @default.
- W2360876898 modified "2023-09-23" @default.
- W2360876898 title "Role of Cancer Testis Antigen CT45-5 in DNA Damage Response" @default.
- W2360876898 hasPublicationYear "2013" @default.
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