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- W2360883644 abstract "Objective To observe the expression of APC-Cdhl mRNA in injured myeloid tissue after hemi- sected spinal cord injury and further investigate the effect of Cdhl-Anaphase-Promoting Complex (APC Cdhl) after spinal cord injury. Methods 40 male Sprague-Dawley rats were randomly divided into the control group and the model group. The spinal cords between that of T10-T11 were hemisected by microscissor after removing the lamina of vertebral and spinous processes. At different time points after injury, Combinea behavioural score (CBS) was employed and the expression of APC-Cdhl mRANA of the lesioned cord was observed by quantitive real time PCR and examined by immunohistochemistry. Results The results showed that the difference of the CBS assessment between in the control group and model group was significant. Compared with the control group, the expression of Cdhl mRNA was significantly decreased at 1 day after injury (P 0.05) and increased obviously at 7 days (P0.05), but decreased again at 14 days (P0.05). The immuno-staining showed that Cdhl was highly expressed in the anterior horn and posterior horn of the spinal cord. Conclusions APC-Cdh1 is highly expressed in spinal cord tissue and may be involved in the pathophysiological process of repairment in the spinal cord injury." @default.
- W2360883644 created "2016-06-24" @default.
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- W2360883644 date "2009-01-01" @default.
- W2360883644 modified "2023-09-25" @default.
- W2360883644 title "Expression of Cdh1-anaphase-promoting Complex(APC-Cdh1)in the Injured Myeloid Tissue after Hemi-seeted Spinal Cord Injury in Rats" @default.
- W2360883644 hasPublicationYear "2009" @default.
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