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- W2360892103 abstract "AIM:To observe the effects of curcumin on the activity of superoxide dismutase(SOD) and the level of lipid peroxides in adult mice and aged rats. METHODS:curcumin was given intraperitoneally to adult NIH mice for seven days. The activity of SOD and the levels of malonaldehyde (MDA) in mouse plasma, liver and brain were determined. 0 02% curcumin was given to aged Sprague Dawley ♂ rats (28 months) as drinking water for nine weeks. The activity of SOD and content of MDA in plasma were determined after curcumin administration. RESULTS:The levels of MDA in mouse plasma and brain were significantly decreased, and the activities of SOD in mouse plasma, brain and liver were significantly increased, both in a dose dependent manner. The MDA level in aged rats plasma was significantly decreased 3 weeks after curcumin administration, and remained low during the experiment. The plasma SOD activity of aged rats was temporarily increased 3 weeks after curcumin administration. CONCLUSIONS:The results indicate that curcumin has the inhibitory effect on lipid peroxidation in adult mice and aged rats. Besides its free radical scavenging function, the anti lipoperoxydating effect of curcumin may be partially related to its enhancement on the activity of SOD." @default.
- W2360892103 created "2016-06-24" @default.
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- W2360892103 date "1997-01-01" @default.
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- W2360892103 title "Effects of curcumin on superoxide dismutase and lipid peroxide in adult mice and aged rats" @default.
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