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- W2360898816 abstract "Objective To investigate the expressions of ILK,PI3K and PTEN proteins in pathologic scar.Methods SP immunohistochemical method was used to detect the expressions of ILK,PI3K and PTEN proteins in 40 cases of pathologic scar,20 cases of non-pathologic scar and 20 cases of normal skin tissue.Results The positive rates of ILK and PI3K proteins in 40 cases of pathologic scar were 67.50%,70.00% and were higher respectively compared with the two control groups(P0.0167);The rate of PTEN proteins in pathologic scars group was 25.00%,significantly lower than the others(P0.0167).Anegative correlation was found between the expression of PTEN and PI3K or ILK proteins(P0.05) in pathologic scar,and there was a highly positive correlation between PI3K and ILK protein expression(P= 0.000,r=0.63).Conclusion ILK,PI3K and PTEN protein might be involved in the formation of pathologic scar through the activation of PTEN/PI3K/ILK/PKB signaling pathway to accelerate fibroblast proliferation.PI3K and ILK proteins may cooperate to promote the progress of pathologic scar." @default.
- W2360898816 created "2016-06-24" @default.
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- W2360898816 date "2009-01-01" @default.
- W2360898816 modified "2023-09-26" @default.
- W2360898816 title "Expressions of ILK,PI3K and PTEN protein in pathologic scar" @default.
- W2360898816 hasPublicationYear "2009" @default.
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