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- W2360911518 abstract "To observe the inhibiting effect of oleanolic acid(OA) on esophageal cancer Eca-109 cell in vitro.Esophageal cancer Eca-109 cells were cultivated in vitro and interfered by different concentrations of oleanolic acid for 24,48 and 72 hours respectively.The inhibiting effect of OA on Eca-109 cells was detected with MTT assay and microscope.1) Eca-109 cell kept proliferating in 5-20μg/ml concentration.Compared with negative control group,40-160μg/ml concentration of OA had effect on esophageal cancer Eca-109 cell after 24,48 and 72 hours respectively,and there was dose-time effect relation between OA and esophageal cancer Eca-109 cell proliferation.In addition,the maximum growth inhibition ratio reached to 87.9%.2) OA had an inhibiting effect on the esophageal cancer Eca-109cells.At the same time an interaction effect between time and dose was observed.When the intervention time was 48 hours and the dose was 160μg/ml,the dose-time was optimal combination.3) Under microscope,it's obvious that the cell growth of pharmacy group had been inhibited.Meanwhile,the number and size of cytoplasma granulae increased and the cell morphology had clearly changed;a part of cells became round,and suspended in the culture medium.Conclusion:OA has distinct inhibitory action on esophageal cancer Eca-109 cell proliferation in a certain concentration range." @default.
- W2360911518 created "2016-06-24" @default.
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- W2360911518 date "2012-01-01" @default.
- W2360911518 modified "2023-09-25" @default.
- W2360911518 title "Inhibiting Effect of Oleanolic Acid on Esophageal Cancer Cells Eca109" @default.
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