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- W2360919164 abstract "Objective:To compare the efficacy and toxicity between IP(irinotecan plus cisplation)and TP( topotecan plus cisplatin)regimen in the second-line treatment of recurrent small cell lung cancer. Methods:Sixty-two cases of recurrent small cell lung cancer were enrolled. Thirty cases were treated with IP regiment (irinotecan 60mg/m2,d1,d8,cisplation 25mg/m2 iv gtt d1-d3),32 cases were treated with TP regiment (topotecan 0.75mg/m2 iv gtt d1-d5,cisplation 25mg/m2 iv gtt d1-d3). Results:For the cases with IP regimen,the overall response rate was 33.3%(10/30). For the cases with TP regimen,the overall response rate was 37.5%(12/32). There was no significant difference between two groups(P0.05). Major toxicity was myelosuppression. Ⅲ-Ⅳgrade leucocytopenia for TP regimen was higher than IP regimen(31.25% versus 23.3%,P0.05),Ⅲ-Ⅳgrade thrombocytopenia for TP regimen was higher than IP regimen(18.8% versus 6.6%,P0.05),tardive diarrhea for IP regimen was higher than TP regimen(30.0% versus 3.1%,P0.01). Conclusion:TP and IP regimen in the second-line treatment of recurrent small cell lung cancer has good chinical efficancy and tolerability." @default.
- W2360919164 created "2016-06-24" @default.
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- W2360919164 date "2008-01-01" @default.
- W2360919164 modified "2023-09-23" @default.
- W2360919164 title "Comparative study of combined chemotherapy between irinotecan plus cisplation regimen and topotecan plus cisplation regimen in relapsed advanced small cell lung cancer" @default.
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