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- W2360920386 abstract "Objective To explore the clinical significance of the injury of vascular endothelial cells and elevated plasma level of inter-leukin-6 (IL-6) in patients with type 2 diabetes mellitus (DM). Methods The number of circulating endothelial cells (CEC) and plasma IL-6 level were measured in 20 normal controls(NC group) and 45 cases of type II DM, including 23 cases without albuminuria (SDM group) and 22 cases with trace albuminuria (EDN group). Results ①The CEC number and IL-6 level markedly elevated in SDM group( P 0.05, all) and EDN group( P 0.01, P 0.05, respectively) than in NC group. ②The CEC number in EDN group was significantly higher than that in SDM group( P 0.01).③Multiple stepwise regression analysis showed that there was significant positive correlation between the CEC number and plasma IL-6 level and urine albumin excretion rate(β = 0.264, P = 0.033 and /? = 0.545, P = 0.000,respectively) . Conclusion The damage of vascular endothelial cells relates to high plasma IL-6 level in the patients with type Ⅱ diabetes mellitus and pkys an important role in the development of diabetic nephropathy." @default.
- W2360920386 created "2016-06-24" @default.
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- W2360920386 date "2004-01-01" @default.
- W2360920386 modified "2023-09-23" @default.
- W2360920386 title "Significance of elevated plasma interleukin-6 level and circulating endothelial cells number in type 2 diabetes mellitus" @default.
- W2360920386 hasPublicationYear "2004" @default.
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