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- W2360931672 abstract "OBJECTIVE:To investigate the effect of aspirin on the inhibitory effects of sirolimus against proliferation of gastric cancer MKN45 cells in vitro,and to elucidate its possible mechanism.METHODS:Gastric cancer MKN45 cells were treated with sirolimus(0,0.5,1.0,2.0 nmol·L-1)or aspirin(10 mmol·L-1)combined with sirolimus(0,0.5,1.0,2.0 nmol·L-1)in vitro.MTT assay was used to detect the growth inhibitory rate of MKN45 cells.The real-time PCR was performed to examine the expression of cycloxyenase-2(COX-2) and interleukin-1 α(IL-1 α) in normal gastric epithelial cell GES-1,normal MKN45 cells and MKN45 cells treated with sirolimus(2.0 nmol·L-1),aspirin alone and two drugs combination.RESULTS:The proliferation of MKN45 cells were inhibited by sirolimus in dosage-dependant manner.Compared with sirolimus alone,inhibition rate of aspirin combined with sirolimus on MKN45 cells was increased significantly(P0.01).mRNA expression of COX-2 MKN45/GES-1 、IL-1α MKN45/GES-1 were 1.49±0.17 and 1.58±0.19.Compared with MKN45 cells in control group,the expression of COX-2 and IL-1α in treated MKN45 cells were decreased significantly(P0.01),there was statistical difference among groups(P0.05 or P0.01).CONCLUSIONS:The combination treatment of aspirin and sirolimus improve the sensitivity of gastric cancer MKN45 cells to sirolimus;the mechanism perhaps lies in the combination of the two drugs to inhibit the expression of COX-2 and IL-1α." @default.
- W2360931672 created "2016-06-24" @default.
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- W2360931672 date "2012-01-01" @default.
- W2360931672 modified "2023-09-25" @default.
- W2360931672 title "Effects of Aspirin on the Inhibitory Effects of Sirolimus against Proliferation of Gastric Cancer MKN45 Cells in Vitro" @default.
- W2360931672 hasPublicationYear "2012" @default.
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