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- W2360952493 abstract "AIM To investigate the effect ofYulangsan(YLS)extract on pleuritis induced by carrageenan. METHODS Fifty-six Wistar male rats were randomly divided into normal group,model group,dexamethasone (DEX)group,high-and low-dose groups of total Yulangsan water extract(TYLS)and flavonoids extract from the roots of YLS(FYLS).The animals were intragastrically treated with drugs for 7 days.Modeling was performed with the method of the carrageenan injection into pleural cavity 30 rain after the last medication.The amounts of pleurorrhea,leucocyte,protein,dinoprostone(PGE_2)and malondial dehyde(MDA)and the activities of superoxide dismutase(SOD)and myeloperoxidase(MPO)in the pleurorrhea were measured 8 h after the modeling.RESULTS As compared with the normal group,the pleurorrhea volume and leukocyte count of rats in the model group were increased(P0.01).Compared with the model group,TYLS and FYLS group could reduce the pleurorrhea volume,leukocyte count,protein,PGE_2 and MDA contents,and MPO activity,and increase SOD level.CONCLUSION YLS extracts show a marked inhibitive effect on pleuritis probably through the mechanism of inhibiting the increase of mediators of inflammatory PGE_2 mediator, suppressing the infiltration and transmigration of leucocytes,and attenuating free radicals,etc.to provide anti- inflammatory response." @default.
- W2360952493 created "2016-06-24" @default.
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- W2360952493 date "2008-01-01" @default.
- W2360952493 modified "2023-09-24" @default.
- W2360952493 title "Effects of Yulangsan extracts on acute pleuritis induced by carrageenan in rats" @default.
- W2360952493 hasPublicationYear "2008" @default.
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