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- W2360953708 abstract "Objective To observe the therapeutic effect of a complex prescription of Shenxiaokang on DN rats and discuss the mechanism of action in the treatment of DN,then provide experimental data for clinical practice. Methods The male model Wistar rats were established with multiple injections of low dose STZ and high calorie diet.Kinds of examination methods were applied,including radiommunoassay,biochemistry,light microscope,electron microscrope,immunohistochemical,Affymetrix Co.US.Rat 2302.0 gene expression profiling chip,and real time quantitative reverse transcription polymerase chain reaction technique to observe the effect of Shenxiaokang on indicators.Cluster analysis method especially applied was to make certain important associated genes with DN,and further applied RT-PCR to do confirmatory experiment. Results eIF3s8 gene was down-regulated in the DN model group and up-regulated in the Shenxiaokang treatment group. Conclusion It was the first time at home and abroad to apply Affymetrix Co.US.Rat 2302.0 gene expression profiling chip to test diabetic nephropathy rats renal tissues genes expresstion in which.eIF3s8 gene was one of the renal tissues difference expresstion and drug effect targets,and to apply real time quantitative reverse transcription polymerase chain reaction technique to analyze it.Gene function analysis show that,the eIF3s8 gene is down-regulated in the DN model group rat kidneys.It is important associated with diabetic kidney damage,and up-regulated in the Shenxiaokang treatment group rat kidneys,Shenxiaokang has benign effect on eIF3s8 gene expresstion.Its mechanism remains to be studied further." @default.
- W2360953708 created "2016-06-24" @default.
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- W2360953708 date "2012-01-01" @default.
- W2360953708 modified "2023-09-23" @default.
- W2360953708 title "Effect of ShenXiaoKang on Diabetic Nephropathy Rats Renal Tissues Gene-eIF3s8 Expression" @default.
- W2360953708 hasPublicationYear "2012" @default.
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