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- W2360973344 abstract "Objective: To investigate the possibility of autophagic death of K562 cell induced by diallyl disulfide(DADS) and its possible mechanisms. Methods: K562 cells was treated by 40mg/L DADS for 12 hours. Its ultrastructure was observed by transmission election microscopy(TEM); Using monodansylcadaverin(MDC) staining, the autophagic vacuoles(AV) was observed by fluorescence microscope and the rates of autophagy was analyzed by flow cytometry; RT-PCR was employed to detect the expression levels of Beclin1mRNA. Results: After treatment with DADS, large amount of autophagosomes were observed in cytoplasm of K562 cell by TEM. Compared with blank reference group and the vehicle group, the autophagic vacuoles determined by MDC staining fluorescence microscope were increased significantly in DADS medication group. And the autophagy rate of blank reference group, vehicle reference group and DADS medication group, measured by means of flow cytometer, were(7.27±5.60)%,(7.10±5.13)%,(27.39±6.51)%(P0. 05) respectively. Higher Beclin1mRNA expression level(0.911±0.008) was found in DADS medication group compared with blank reference group(0.658±0.007) and vehicle reference group(0.671±0.012), while no significant difference was observed between those contorl groups. Conclusion: DADS can induce autophagic death of leukemia K562 cell, the autophagic death may be related to the up-regulation of Beclin1 mRNA expression." @default.
- W2360973344 created "2016-06-24" @default.
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- W2360973344 date "2014-01-01" @default.
- W2360973344 modified "2023-09-23" @default.
- W2360973344 title "Diallyl Disulfide Raised Beclin1 Mediated Autophagy in Leukemia K562 Cell" @default.
- W2360973344 hasPublicationYear "2014" @default.
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