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- W2360994731 abstract "Objective To evaluate expression and clinical significance of telomerase activity,P53 and nm23 in primary colorectal carcinoma.Methods The expression of P53 and nm23 were examined by immunohistochemical technique in 100 cases of colorectal carcinoma.Telomerase activity was examined by using in situ hybridization mRNA of telomerase.The relationship between the expression and clinical-pathological behaviors were analyzed.Results The positive expression of telomerase activity in cancer tissues was significantly higher than that in adjacent cancer tissues and in normal tissues(P0.05).Telomerase activity level in colorectal carcinoma was significantly associated with the invasion,clinicopathologic stage and lymph node metastasis(P0.05).The expression of P53 had a relevancy with the grade and clinical stage(P0.05).A minor relationship was observed between P53 over-expression and nm23 low-expression(r=-0.115).Conclusion The expression and level of telomerase activity,P53 gene and nm23 mutation play some roles in development of colorectal carcinoma.They might be a good sign and helpful in diagnosis,treatment and prognostic evaluation of colorectal carcinoma.The expression of P53 and nm23 examined simultaneously might be valuable." @default.
- W2360994731 created "2016-06-24" @default.
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- W2360994731 date "2010-01-01" @default.
- W2360994731 modified "2023-09-24" @default.
- W2360994731 title "Expression and clinical significance of telomerase activity,P53 and nm23 in colorectal carcinoma" @default.
- W2360994731 hasPublicationYear "2010" @default.
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