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- W2360999856 abstract "AIM To investigate the effect of long term using cocaine on internal carotid artery among the African-American young adults in Baltimore,Maryland.METHODS 57 participants had been interviewed for sociodemographics,drug-use behaviors,had had tests of lipid profiles and high-sensitivity C-reactive protein and MRI was performed to detect the internal carotid artery vessel,then,multi-variates linear regression model was used to analyze the correlations of long term cocaine exposure with the carotid artery vessel change.RESULTS Of the 57 study participants,the cocaine user group(n=40) had no significantly but a slightly elevated levels of CRP[(5.14±12.31) vs(1.29±0.92)μg/L,P=0.059],WBC[(5.03±1.70) vs(4.12±1.22)×109/L,P=0.059],no significantly but a slightly lower levels of MCH[(29.34±2.18) vs(31.77±4.50)pg,P=0.055],MCHC[(33.23±0.75) vs(33.67±0.49)g/dl,P=0.38] with non-cocaine user group(n=17).There was neither significant difference of the mean thickness of internal carotid vessel(MTICV) between the cocaine users group(0.952±0.244)cm with non-cocaine users group [(0.968±0.275)cm,P=0.822],nor significant difference of the percent of MTICV1.0 cm as the wall being thicken between the two groups(25% of cocaine users vs 29.4% of non cocaine users,P=0.729).Using univariate liner regression model,we found that the horizontal outer contour diameter(HOD),vertical inner lumen diameter(VID),outer area of contour(OA),inner lumen area(ILA),outer volume(OV) and lumen volume(LV) of the internal carotid artery vessel contour had significant negative correlation with cocaine use.The horizontal inner lumen diameter(HID),vertical outer contour diameter(VOD),vertical thickness of vessel wall(VTW),horizontal thickness of the vessel wall(HTW),the thickest vessel wall(TVW) and MTICV had no significant relationship with cocaine using.Multiple-variates linear regression model showed only the cocaine use had significant negative correlation with the HOD,VID,OA,ILA,OV and LV of the internal carotid artery vessel contour while HIV infection,age,gender,BMI and CRP had no significant correlation with the internal carotid artery vessels changes.CONCLUSIONS long-term cocaine using had the effect of contraction on the internal carotid artery vessel.Because the contraction may initiate a cascade of brain tissue ischemia and brain vessel atherosclerosis,we may get the hypothesis that long term use of cocaine may have the effect of vasoconstriction as an early stage of atherosclerosis on the artery system of human beings." @default.
- W2360999856 created "2016-06-24" @default.
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- W2360999856 date "2007-01-01" @default.
- W2360999856 modified "2023-09-25" @default.
- W2360999856 title "Effects of long term cocaine use on the caliber of internal carotid artery in an African-American population" @default.
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