Matches in SemOpenAlex for { <https://semopenalex.org/work/W2361001497> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2361001497 abstract "Objective FSM 2117,FS 5416,FS 5414,FS 5411 and FS 5402 are two types of bivalent hybrid strains of S. flexneri and S. sonnei, constructed by our laboratory, The FS 5416,FS 5414,FS 5411 and FS 5402 express four invasive plasmid antigens and can be invasive to Hela cells(inv+), but the FSM 2117 does not(inv-). To observe the differences of the two types of bivalent shigella vaccines in immune responses and memory responses, we detected the antibodies of shi gella flexneri and sonnei LPS after three times immunization and boosting immunization after 20 weeks.Methods Using the ELISA assay, the changes of specific antibodies of mice (the levels of SIgA and IgG) were detected after immunization with five different vaccines and boosting immunization after an interval of 20 weeks. Results We observed significant rises in different mucosal sites wash and serum on the two times immunization.Significant differences were observed between two immunized groups and the control. Both of the two types of bivalent shigella vaccines showed memory response, but the levels of antibodies were lower than that of the third immunization. Conclusion Two types of shigella vaccines can induce antigen specific antibodies not only in several mucosal sites but also in serum after three times immunization. They can arose the memory immune responses not only in local nasal site but also in the other mucosal sites and serum. The expression of invasive plasmid antigens can improve the level of antibodies immune responses and the memory responses." @default.
- W2361001497 created "2016-06-24" @default.
- W2361001497 creator A5069142544 @default.
- W2361001497 date "2002-01-01" @default.
- W2361001497 modified "2023-09-25" @default.
- W2361001497 title "Detection of memory responses of specific antibodies in local mucosa and serum after intranasal immunization with two bi-valent Shigella vaccines in mice" @default.
- W2361001497 hasPublicationYear "2002" @default.
- W2361001497 type Work @default.
- W2361001497 sameAs 2361001497 @default.
- W2361001497 citedByCount "0" @default.
- W2361001497 crossrefType "journal-article" @default.
- W2361001497 hasAuthorship W2361001497A5069142544 @default.
- W2361001497 hasConcept C104317684 @default.
- W2361001497 hasConcept C147483822 @default.
- W2361001497 hasConcept C159047783 @default.
- W2361001497 hasConcept C159654299 @default.
- W2361001497 hasConcept C178790620 @default.
- W2361001497 hasConcept C185592680 @default.
- W2361001497 hasConcept C203014093 @default.
- W2361001497 hasConcept C22070199 @default.
- W2361001497 hasConcept C2776620830 @default.
- W2361001497 hasConcept C2780801004 @default.
- W2361001497 hasConcept C2781217973 @default.
- W2361001497 hasConcept C544153396 @default.
- W2361001497 hasConcept C547475151 @default.
- W2361001497 hasConcept C55493867 @default.
- W2361001497 hasConcept C85663871 @default.
- W2361001497 hasConcept C86803240 @default.
- W2361001497 hasConcept C8891405 @default.
- W2361001497 hasConcept C89423630 @default.
- W2361001497 hasConceptScore W2361001497C104317684 @default.
- W2361001497 hasConceptScore W2361001497C147483822 @default.
- W2361001497 hasConceptScore W2361001497C159047783 @default.
- W2361001497 hasConceptScore W2361001497C159654299 @default.
- W2361001497 hasConceptScore W2361001497C178790620 @default.
- W2361001497 hasConceptScore W2361001497C185592680 @default.
- W2361001497 hasConceptScore W2361001497C203014093 @default.
- W2361001497 hasConceptScore W2361001497C22070199 @default.
- W2361001497 hasConceptScore W2361001497C2776620830 @default.
- W2361001497 hasConceptScore W2361001497C2780801004 @default.
- W2361001497 hasConceptScore W2361001497C2781217973 @default.
- W2361001497 hasConceptScore W2361001497C544153396 @default.
- W2361001497 hasConceptScore W2361001497C547475151 @default.
- W2361001497 hasConceptScore W2361001497C55493867 @default.
- W2361001497 hasConceptScore W2361001497C85663871 @default.
- W2361001497 hasConceptScore W2361001497C86803240 @default.
- W2361001497 hasConceptScore W2361001497C8891405 @default.
- W2361001497 hasConceptScore W2361001497C89423630 @default.
- W2361001497 hasLocation W23610014971 @default.
- W2361001497 hasOpenAccess W2361001497 @default.
- W2361001497 hasPrimaryLocation W23610014971 @default.
- W2361001497 hasRelatedWork W1969435176 @default.
- W2361001497 hasRelatedWork W2005709155 @default.
- W2361001497 hasRelatedWork W2012094064 @default.
- W2361001497 hasRelatedWork W2026776204 @default.
- W2361001497 hasRelatedWork W2051835014 @default.
- W2361001497 hasRelatedWork W2071114162 @default.
- W2361001497 hasRelatedWork W2078598660 @default.
- W2361001497 hasRelatedWork W2091561373 @default.
- W2361001497 hasRelatedWork W2157035238 @default.
- W2361001497 hasRelatedWork W2160332258 @default.
- W2361001497 hasRelatedWork W2344890689 @default.
- W2361001497 hasRelatedWork W2349576964 @default.
- W2361001497 hasRelatedWork W2351564335 @default.
- W2361001497 hasRelatedWork W2354944585 @default.
- W2361001497 hasRelatedWork W2357379806 @default.
- W2361001497 hasRelatedWork W2384309600 @default.
- W2361001497 hasRelatedWork W2387054964 @default.
- W2361001497 hasRelatedWork W3141357433 @default.
- W2361001497 hasRelatedWork W3149458020 @default.
- W2361001497 hasRelatedWork W3214157482 @default.
- W2361001497 isParatext "false" @default.
- W2361001497 isRetracted "false" @default.
- W2361001497 magId "2361001497" @default.
- W2361001497 workType "article" @default.