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- W2361003990 abstract "The aim of this study is to investigate the effects of stretch on growth and metabolism of cardiac myocytes in vitro.Cardiac myocytes from ventricles of neonatal rats were isolated and cultured on silicone membranes.The silicone membranes were stretched cyclically and the two-Dimensional finite element model was developed to analyze the strain distribution of the membrane.The cells morphology was observed by a phase contrast microscope after cultured under cyclic stretch with different frequency.The contents of glucose and lactic acid in the supernatant were assayed to determine the metabolism of cells.Intracellular βtubulin expression was analyzed by western blot.Most of the cardiac myocytes grew well on the membranes experiencing cyclic stretch and express α-sacromeric actin and desmin.Morphology of the cells changed from polygon to rhabditiform,and the orientation of cells altered.When the strain frequency was fixed at 1 Hz,the specific glucose consumption rate,the specific lactate production rate and the polymeric tubulin content of 8% strain group were obviously higher than those of static group(P0.05).When the strain magnitude was fixed at 8%,stimuli of 1 Hz strain gave the most enhancement to metabolism of the cells(P0.01). The polymeric tubulin contents in all frequency levels were higher than that of static group when strain magnitude was 8%.Proper mechanical stretch could improve the metabolism and polymeric tubulin contents of cardiac myocytes in vitro." @default.
- W2361003990 created "2016-06-24" @default.
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- W2361003990 date "2009-01-01" @default.
- W2361003990 modified "2023-09-25" @default.
- W2361003990 title "The Response of Metabolism and Tubulin of Cardiac Myocytes in vitro to Mechanical Stretch" @default.
- W2361003990 hasPublicationYear "2009" @default.
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