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- W2361005590 abstract "Objective To investigate the mechanisms of carotid artery intima-media thickness(IMT)by characterizing the relationships between carotid artery IMT and the serum levels of interleukin 18.Methods Carotid artery IMT values were prospectively measured using color Doppler ultrasound in forty transient ischemia attack(TIA)patients and sixty-four acute cerebral infarct(ACI)patients,who constitute the study group,as well as thirty health volunteers as control group.The study groups were divided into two subgroups according to IMT larger or lower than 1.0 mm.Serum IL-18 levels were determined in all patients and volunteers with enzyme-linked immunosorbent assay(ELISA)respectively.Results There were significant differences in IL-18 levels between study group and control group(P﹤0.01,respectively).The IL-18 levels between IMT≥1.0 mm and IMT﹤1.0 mm subgroups in study group both had statistic differences(P﹤0.05),no difference was found between study group and control group when IMT﹤1.0mm in study group.The levels of serum IL-18 were positively correlated with IMT values in study group(Pearson correlation coefficients r=0.549,P=0.000).Conclusions The levels of serum IL-18 are increased in TIA and ACI patients.With IMT≥1.0mm Serum IL-18 level is positively correlated with carotid artery IMT.IL-18 may involve in the development of AS." @default.
- W2361005590 created "2016-06-24" @default.
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- W2361005590 date "2009-01-01" @default.
- W2361005590 modified "2023-09-23" @default.
- W2361005590 title "Preliminary study of relationships between carotid artery intima-media thickness and serum interleukin-18" @default.
- W2361005590 hasPublicationYear "2009" @default.
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