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- W2361006870 abstract "Objective To determine the effects cerebral ventricular injection of the intermedin1-53 fragment on mean arterial blood pressure and heart rate in normal rats and its possible mechanism. Methods Rats were given intermedin1-53(IMD1-53) or adrenomedullin intracerebroventricularly(ICV). Blood pressure and heart rate was monitored for 45 min. Results The ICV injection of intermedin1-53 (0.1, 0.5 and 1.0 nmol/kg) resulted in a dose and time related increases in mean arterial pressure and heart rate. The effects were more prominent than that by equivalent dose of adrenomedullin. The CNS action of intermedin1-53 was blocked by ADM22-52 or prepro-IMD antibody. Conclusion These data suggest that central injection of intermedin 1-53 may regulate BP and HR." @default.
- W2361006870 created "2016-06-24" @default.
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- W2361006870 date "2006-01-01" @default.
- W2361006870 modified "2023-09-26" @default.
- W2361006870 title "Effects of Cerebral Ventricular Injection of Intermedin1-53 on Mean Arteral Pressure and Heart Rate in Conscious Rats" @default.
- W2361006870 hasPublicationYear "2006" @default.
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