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- W2361006918 abstract "Objective Ⅱ mixture can induce liver fibrosis in rat hepatic stellate cells,and make bcl-2,bcl-2a,bax protein expression.Methods 50 male SD rats weighing 200g ± 25g,50 rats were used 40%(V/V) carbon tetrachloride solution by 0.15mL/100g subcutaneously 2 times a week,continuous medication 8wk after random of which five were killed confirmed the formation of hepatic fibrosis model,the remaining 45 were randomly divided into blank group(A) 20,model group 5(C),the treatment group(B) 20,B group 20 to the liver Ⅱ mixture 4mL/(100g d) fed 8wk,A group of 20,with the same amount of saline fed 8wk.the end of treatment,C group,model group.Using terminal deoxynucleotidyl transferase-mediated nick end labeling detection of liver cell apoptosis,using immunohistochemical staining bcl-2 bcl-2a and bax.Results In group B and A,C group,B group significantly reduced the number of hepatic stellate cells and apoptosis of hepatic stellate cells increased the apoptosis index increased significantly,P 0.05,B group of bcl-2 bcl-2a and bax protein increased significantly.Conclusion Ⅱ mixture can induce liver fibrosis in rat hepatic stellate cells,and make bcl-2,bcl-2a,bax protein expression." @default.
- W2361006918 created "2016-06-24" @default.
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- W2361006918 date "2013-01-01" @default.
- W2361006918 modified "2023-09-23" @default.
- W2361006918 title "Effects of Second Mixture on Liver Fibrosis of Liver in Rat Hepatic Stellate Cells (HSC) of Apoptosis and Expression of Related Proteins" @default.
- W2361006918 hasPublicationYear "2013" @default.
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