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- W2361008092 abstract "The pollutants which have the same mode of action or even the molecular site of action usually support toxicity additivity for mixtures. But each has its own degree of toxicity. To express the overall toxicity of such a mixture as a single number, the concept of Toxic Equivalents (TEQ) has been developed. Five PAHs with high Ah-accepter-effect were detected by EROD assay in H4 II E hepetoma cell line. The dose-effect relationship and toxicity equivalent factors (ERODTEF) were calculated. The study shows that the EC50 of PAHs investigated are different and the toxicity of PAHs rank as follows: BkfI(cd)PBap Bbf Chr showing the EROD-TEF are 1.1×10-4、3.0×10-5、3.9×10-6、2.8×10-6and 1.5×10-6 respectively. The concentrations of 16 PAHs in sediments were determined by gas chromatography equipped with a mass spectrometry(GC-MS). The total PAH levels were expressed as 2, 3, 7, 8-TCDD toxicity equivalents (TEQPAH) calculating by the factor of EROD-TEF and compared to the total toxicity equivalents (EROD-TEQ) tested by the in vitro EROD induction bioassay. The result shows that the TEQPAH values were in good correlation with the EROD - TEQ (r2 = 0.65, p0.05)and the EROD-TEF can be used in environmental sample. The TEQPAH accounted for more than 50% of the EROD-TEQ. PAHs were the dominant contributor to the effect of Ah accepter in the sediment of Meiliang Bay, Taihu Lake. Considering this information, the environment risk of PAHs may not be ignored." @default.
- W2361008092 created "2016-06-24" @default.
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- W2361008092 date "2006-01-01" @default.
- W2361008092 modified "2023-09-28" @default.
- W2361008092 title "Detection of Toxicity Equivalent Factors for Five PAHs and Studies on Its Usage in the Sediment of Meiliang Bay, Taihu Lake" @default.
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