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- W2361031839 abstract "Objective: To investigate the effects of Shuanghu qinggan granule on hepatic expression of TNF-α and pathological changes of hepatic fibrosis induced by carbon tetrachloride in rats.Methods :60 Sprague-Dawley rats were divided into 6 groups,namely normal control group(group A),model group(group B),Shuanghu qinggan granule small,middle,large dose groups(groupC1,C2,C3) and silymarin contrast group(group D). The rats group B,group C1,C2,C3 and group D were subcutaneously injected with carbon tetrachloride (3mL per kilogram body weight)twice a week for 8 weeks. Then the rats of groupC1,C2,C3 were administered with Shuanghu qinggan granule at different dose for 8 weeks,including 1.2 grams per kilogram body weight (groupC1),2.5 grams per kilogram body weight (groupC2),5 grams per kilogram body weight(groupC3).The rats of group D were then administered with silymarin at the dose of 50 milligram per kilogram body weight. The levels of serum TNF-α of all rats were measured respectively under the same condition and at the same time by elisa. The pathological changes of hepatic fibrosis and the density of collagen in liver specimens of all rats were assessed through HE and Masson staining.Results :Compared with group B, lipid vacuoles and liver necrosis were significantly reduced, and false lobular formation of collagen deposition was significantly decreased in group C3 and D. There was fibrosis difference between group C1, C2, C3 and group D (12.6 ± 4.6, 10.7 ±3.9, 6.4 ± 3.4, 6.5 ± 3.3 vs 16.1±5.5, all P 0.05)。 Serum TNF-α levels were lower in group C1,C2,C3, D than in group B (19.15±4.86,11.28±3.43, 9.93±5.31,9.37±5.02,10.86±5.28 vs 8.01±3.45, P0.001 or 0.05). Conclusion :Shuanghu qinggan granule has obvious effects on hepatic expression of TNF-α and pathological changes of hepatic fibrosis induced by carbon tetrachloride in rats. Significant difference was found in fibrosis values,and the higher dosage of Shuanghu qinggan granule was more effective." @default.
- W2361031839 created "2016-06-24" @default.
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- W2361031839 date "2009-01-01" @default.
- W2361031839 modified "2023-09-23" @default.
- W2361031839 title "Effects of Shuanghu Qinggan Granule on Hepatic Expression of TNF-α and Pathological Changes of Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats" @default.
- W2361031839 hasPublicationYear "2009" @default.
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