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- W2361032804 abstract "Objective: To investigate the effects of interleukin 1α(IL-1α) and its receptor antagonist(IL-1ra) on the proliferation and invasion of human colon cancer cells with different metastatic potentials as well as the role of IL-1α and IL-1ra in metastatic process. Methods: The colonic carcinoma cell lines with high liver metastatic potential(WiDr) and low liver metastatic potential(Caco-2 and Colo-320) were used.The gene and protein expressions of IL-1α and its type I receptor(IL-1R I) were determined by RT-PCR and ELSIA assay,respectively.After exposure to different concentrations of the exogenous IL-1α and IL-1ra,the cell proliferation of the three cell lines was measured by WST-1 assay and the invasive ability of WiDr and Caco-2 cells was assessed by using Transwell chamber. Results: The RT-PCR results showed that the IL-1α mRNA was only expressed in the WiDr cells of high liver metastatic potential but not in Caco-2 and Colo-320 cells of low liver metastatic potential,while the IL-1R I gene was expressed in all the three types of cells.The concentration of IL-1α protein detected in WiDr cells by ELISA assay was(7.85±0.52) pg/mL but was not detected in Caco-2 and Colo-320 cells.The exogenous IL-1α significantly increased the proliferative ability of Caco-2 and Colo-320 cells(all P0.05),but had no effect on that of WiDr cells(P0.05),while the exogenous IL-1ra markedly inhibited the proliferation of WiDr cells(P0.05).The exogenous IL-1α significantly enhanced the invasive ability of Caco-2 cells(P0.05),but had no influence on that of WiDr cells(P0.05);the exogenous IL-1ra significantly inhibited the invasiveness of WiDr cells(P0.05),but had no effect on Caco-2 cells(P0.05). Conclusion: The liver metastatic potential of colon cancer is related to its IL-1α expression,and exogenous IL-1ra can inhibit the proliferative and invasive ability of colon cancer cells." @default.
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- W2361032804 date "2012-01-01" @default.
- W2361032804 modified "2023-09-23" @default.
- W2361032804 title "Effect of interleukin 1α and its receptor antagonist on proliferation and invasion of human colon cancer cell lines" @default.
- W2361032804 hasPublicationYear "2012" @default.
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