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- W2361036359 endingPage "24" @default.
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- W2361036359 abstract "Calcium influx is an essential mechanism for the activation of cellular functions both in excitable and non-excitable cells. In non-excitable cells, activation of phospholipase C by occupation of G protein-coupled receptors leads to the generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), which, in turn, initiate two Ca2+ entry pathways: Ca2+ release from intracellular Ca2+ stores, signaled by IP3, leads to the activation of store-operated Ca2+ entry (SOCE); on the other hand, DAG activates a distinct second messenger-operated pathway. SOCE is regulated by the filling state of the intracellular calcium stores. The search for the molecular components of SOCE has identified the stromal interaction molecule 1 (STIM1) as the Ca2+ sensor in the endoplasmic reticulum and Orai1 as a store-operated channel (SOC) subunit. Furthermore, a number of reports have revealed that several members of the TRPC family of channels also take part of the SOC macromolecular complex. This introductory chapter summarizes the early pieces of evidence that led to the concept of SOCE and the components of the store-operated signaling pathway." @default.
- W2361036359 created "2016-06-24" @default.
- W2361036359 creator A5005766947 @default.
- W2361036359 creator A5011107308 @default.
- W2361036359 creator A5036708850 @default.
- W2361036359 creator A5080498077 @default.
- W2361036359 date "2016-01-01" @default.
- W2361036359 modified "2023-10-04" @default.
- W2361036359 title "Historical Overview of Store-Operated Ca2+ Entry" @default.
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