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- W2361051628 abstract "Objective To understand the composition differences of inflammation and fibrosis among the different parameters such as age,sex,HBV DNA load,hepatitis B family history in patients with HBeAg-positive chronic hepatitis B.Methods 179 patients with HBeAg-positive chronic hepatitis B were all from our hospital and given liver biopsy within two years.Data were retrospectively analyzed based on the stratified levels of above parameters.Results Most of patients initiating the immune clearance phase were before 30 years old.Patients with fibrosis (moderate and severe) were prevalent after 40 years old.The ratio of male to female was approximately 3.5:1.Male patients with G ≥ 2 was significantly higher than that of female,but there was no difference in composition ratio of fibrosis between men and women.Patients with HBV DNA load at 104～106copies/ml were mostly characterized by moderate to severe inflammation (G≥2,76.5%) and 62.5% patients with HBV DNA104 copies/ml were with moderate to severe fibrosis (S≥2).About 40% of patients had family hepatitis B history.Patients with family history had higher percentage of G ≥ 2 compared to those without family history (71.2% vs 61%),but no difference were observed in fibrosis level between these two groups.Conclusions Composition differences of inflammation and fibrosis were observed in different parameters such as age,sex,HBV DNA load,hepatitis B family history.Our data showed that patients with even before 40-year-old,female,HBVDNA 104copies/ml or without family history should also be paid attention in clinical practice." @default.
- W2361051628 created "2016-06-24" @default.
- W2361051628 creator A5037252959 @default.
- W2361051628 date "2010-01-01" @default.
- W2361051628 modified "2023-09-26" @default.
- W2361051628 title "Analysis of risk factors about disease progression in patients with HBeAg-positive chronic hepatitis B receiving liver biopsy" @default.
- W2361051628 hasPublicationYear "2010" @default.
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