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- W2361052222 abstract "Objective To investigate the effect and mechanism of valstartan on a novel salt-sensitive hypertensive rat induced by sensory denervation.MethodsTwenty two sensory denervated Wistar rats(3 weeks) were divided into 3 groups and subjected to the following treatment for 4 weeks: normal salt diet(0.5%, CAP-NS), high salt diet(4%,CAP-HS), high salt diet +valstartan (30 mg/kg·d, by orally,CAP-HS-VAL). Eight control rats were treated with high salt diet(CON-HS). Tail-cuff systolic blood pressure, body weight, intralymphocytic [Ca~2+ ]i, plasma calcitonin gene-related peptide concentration (CGRP), angiotensin Ⅱ concentration(Ang Ⅱ) and 24 h water intake, urinary volume, urinary Na+ and K+ concentrations were examined.Results Tail-cuff systolic blood pressure and intralymphocytic [Ca~2+ ]i were lower in CAP-HS-VAL group than in CAP-HS group [SBP:(103.6±6.9 vs 143.4±6.6)mm Hg, [Ca~2+ ]i (64.3±6.1 vs 133.7±15.1) mmol/L, P0.001]. Plasma Ang Ⅱ were higher in CAP-HS-VAL group than in CON-HS, CAP-NS and CAP-HS groups [CAP-HS-VAL 809.8±102.7 vs CAP-NS: 403.8±52.4 vs CAP-HS: 217.3±32.0 vs CON-HS 165.4±56.2)pg/mL, P0.001]. Conclusion Valstartan prevents the development of salt-sensitive hypertension and the overloading of intracellular [Ca~2+ ]i in lymphocytes of sensory denervated Wistar fed with high-salt diet. Our data indicates that renin-angiotensin system (RAS) may play a pivotal role in the establishment of sensory denervation induced hypertensive model." @default.
- W2361052222 created "2016-06-24" @default.
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- W2361052222 date "2005-01-01" @default.
- W2361052222 modified "2023-09-23" @default.
- W2361052222 title "The Antihypertensive Effect and Mechanism of Valstartan on A Novel Salt-Sensitive Hypertensive Rat Induced by Sensory Denervation" @default.
- W2361052222 hasPublicationYear "2005" @default.
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