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- W2361062334 abstract "Objective To study the hepatic protective effect of early fluid resuscitation with hydroxyethyl starch(HES) on septic shock in newborn rabbits. Methods 60 New Zealand longear newborn rabbits received cecal ligation and puncture(CLP)were randomly divided into three groups(20 rabbits/group):group I(CLP without liquid),group II(CLP,HES 10 mL·kg-1 plus lactate Ringer's injection 20 mL·kg-1),group III(CLP,HES 30 mL·kg-1).The right carotid artery of rabbits were annulated with a microtip transducer for continuous recording of MAP during the experiment process.The left carotid vein was catheterized to infuse the fixed fluid for 1 hour.Arterial blood samples were taken for blood gas analysis,liver was stained with HE and observed under microscope,and NF-κB protein levels in hepatic tissue were measured at 8 h after CLP. Results Compared with MAP at 0 h,which gradually decreased in group I.No obvious change of blood pressure appeared in both group Ⅱ and Ⅲ.In comparison to group I,blood pressure was elevated after 2 h in group II and Ⅲ(P0.05).The artery PaO2 was higher in groupⅡ and Ⅲ than that in group I(P0.05).No significant difference in pH and PaCO2 were found among three groups.The expression of NF-κB protein in hepatocyte was stronger in group I than that in group Ⅱ and Ⅲ,and which was more in group Ⅲ than in group Ⅱ(P0.05). Conclusion Early fluid resuscitation with HES,especially at 10 mL·kg-1 prosessed protective effect on septic shock in newborn rabbits." @default.
- W2361062334 created "2016-06-24" @default.
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- W2361062334 date "2011-01-01" @default.
- W2361062334 modified "2023-09-23" @default.
- W2361062334 title "Hepatic Protection by Early Fluid Resuscitation with Hydroxyethyl Starch on Septic Shock in Newborn Rabbits" @default.
- W2361062334 hasPublicationYear "2011" @default.
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