Matches in SemOpenAlex for { <https://semopenalex.org/work/W2361066268> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2361066268 endingPage "5" @default.
- W2361066268 startingPage "260" @default.
- W2361066268 abstract "Antibiotic C1027, a macromolecular peptide with highly potent cytotoxicity to cultured cancer cells, was conjugated to monoclonal antibody 3A5 and its Fab fragment separately using SPDP as the linker agent. McAb 3A5, identified as IgG1, was directed against human hepatoma BEL-7402 cells. By ELISA, McAb 3A5 and the Fab fragment were strongly reactive with hepatoma cells and weakly reactive with KB cells. Determined by clonogenic assay against hepatoma BEL-7402 cells, the IC50 values for McAb-C1027, Fab-C1027 and C1027 were 4.2 x 10(-14), 8.6 x 10(-16) and 6.5 x 10(-16) mol.L-1, respectively. Fab-C1027 was 49-fold more potent than McAb-C1027 in cytotoxicity. Moreover, Fab-C1027 was 160-fold more potent in cytotoxicity to hepatoma cells than to KB cells, indicating selective cytotoxicity of Fab-C1027 conjugate to the target cells. Therapeutic effect of the conjugate was evaluated with hepatoma BEL-7402 xenograft in nude mice. After subcutaneous transplantation of the tumor, treatment started on day 3, iv, with equivalent dose of C1027, 0.1 mg.kg-1 x 6. Fab-C1027 and free C1027 inhibited tumor growth by 85% and 59%, respectively. Fab-C1027 conjugate showed more marked antitumor effect in vivo than free C1027." @default.
- W2361066268 created "2016-06-24" @default.
- W2361066268 creator A5003319875 @default.
- W2361066268 creator A5038588938 @default.
- W2361066268 creator A5066521589 @default.
- W2361066268 creator A5067768800 @default.
- W2361066268 date "1993-01-01" @default.
- W2361066268 modified "2023-09-23" @default.
- W2361066268 title "[Antitumor effect of the immunoconjugate composed of antibiotic C1027 and Fab fragment from a monoclonal antibody directed against human hepatoma]." @default.
- W2361066268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8213168" @default.
- W2361066268 hasPublicationYear "1993" @default.
- W2361066268 type Work @default.
- W2361066268 sameAs 2361066268 @default.
- W2361066268 citedByCount "4" @default.
- W2361066268 countsByYear W23610662682012 @default.
- W2361066268 crossrefType "journal-article" @default.
- W2361066268 hasAuthorship W2361066268A5003319875 @default.
- W2361066268 hasAuthorship W2361066268A5038588938 @default.
- W2361066268 hasAuthorship W2361066268A5066521589 @default.
- W2361066268 hasAuthorship W2361066268A5067768800 @default.
- W2361066268 hasConcept C109316439 @default.
- W2361066268 hasConcept C117262875 @default.
- W2361066268 hasConcept C134306372 @default.
- W2361066268 hasConcept C150903083 @default.
- W2361066268 hasConcept C153911025 @default.
- W2361066268 hasConcept C159654299 @default.
- W2361066268 hasConcept C163864487 @default.
- W2361066268 hasConcept C185592680 @default.
- W2361066268 hasConcept C197336794 @default.
- W2361066268 hasConcept C202751555 @default.
- W2361066268 hasConcept C203014093 @default.
- W2361066268 hasConcept C207001950 @default.
- W2361066268 hasConcept C2778556491 @default.
- W2361066268 hasConcept C2780278673 @default.
- W2361066268 hasConcept C2909223937 @default.
- W2361066268 hasConcept C33923547 @default.
- W2361066268 hasConcept C542903549 @default.
- W2361066268 hasConcept C55493867 @default.
- W2361066268 hasConcept C85630698 @default.
- W2361066268 hasConcept C86803240 @default.
- W2361066268 hasConceptScore W2361066268C109316439 @default.
- W2361066268 hasConceptScore W2361066268C117262875 @default.
- W2361066268 hasConceptScore W2361066268C134306372 @default.
- W2361066268 hasConceptScore W2361066268C150903083 @default.
- W2361066268 hasConceptScore W2361066268C153911025 @default.
- W2361066268 hasConceptScore W2361066268C159654299 @default.
- W2361066268 hasConceptScore W2361066268C163864487 @default.
- W2361066268 hasConceptScore W2361066268C185592680 @default.
- W2361066268 hasConceptScore W2361066268C197336794 @default.
- W2361066268 hasConceptScore W2361066268C202751555 @default.
- W2361066268 hasConceptScore W2361066268C203014093 @default.
- W2361066268 hasConceptScore W2361066268C207001950 @default.
- W2361066268 hasConceptScore W2361066268C2778556491 @default.
- W2361066268 hasConceptScore W2361066268C2780278673 @default.
- W2361066268 hasConceptScore W2361066268C2909223937 @default.
- W2361066268 hasConceptScore W2361066268C33923547 @default.
- W2361066268 hasConceptScore W2361066268C542903549 @default.
- W2361066268 hasConceptScore W2361066268C55493867 @default.
- W2361066268 hasConceptScore W2361066268C85630698 @default.
- W2361066268 hasConceptScore W2361066268C86803240 @default.
- W2361066268 hasIssue "4" @default.
- W2361066268 hasLocation W23610662681 @default.
- W2361066268 hasOpenAccess W2361066268 @default.
- W2361066268 hasPrimaryLocation W23610662681 @default.
- W2361066268 hasRelatedWork W1492688798 @default.
- W2361066268 hasRelatedWork W2019543159 @default.
- W2361066268 hasRelatedWork W2028938823 @default.
- W2361066268 hasRelatedWork W2038901808 @default.
- W2361066268 hasRelatedWork W2057007671 @default.
- W2361066268 hasRelatedWork W2065813947 @default.
- W2361066268 hasRelatedWork W2361066268 @default.
- W2361066268 hasRelatedWork W2365490899 @default.
- W2361066268 hasRelatedWork W2468617553 @default.
- W2361066268 hasRelatedWork W29975225 @default.
- W2361066268 hasVolume "28" @default.
- W2361066268 isParatext "false" @default.
- W2361066268 isRetracted "false" @default.
- W2361066268 magId "2361066268" @default.
- W2361066268 workType "article" @default.