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- W2361072064 abstract "Objective To determine the concentration of diclofenac sodium ophthalmic preparation in ocular tissues of rabbit and evaluate its pharmacokinetics.Methods 48 rabbits were divided into two groups and each group included eight time groups with three rabbits.0.1% diclofenac sodium ointment and diclofenac sodium eye drops were applied topically to rabbit eyes and aqueous humor and iris-ciliary were collected at various time.The concentration of diclofenac sodium in ocular tissues was measured by high performance liquid chromatography.Results The blood concentration-time curve of diclofenac sodium fitted in with the two compartment model.Diclofenac sodium ointment had a higher concentration and a longer half-time than diclofenac sodium eye drops,but the peak time was the same at about 1h.Cmax of diclofenac sodium ointment and eye drops in aqueous humor and iris-ciliary were 0.32±0.11 μg/ml,0.41±0.15 μg/ml and 4.18±1.01 μg/mg,5.95±2.09μg/mg,respectively.Conclusion Diclofenac sodium ointment and eye drops can be well absorbed into the ocular tissues for treating various ophthalmological inflammation." @default.
- W2361072064 created "2016-06-24" @default.
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- W2361072064 date "2006-01-01" @default.
- W2361072064 modified "2023-09-23" @default.
- W2361072064 title "Distribution of diclofenac sodium ophthalmic preparation in ocular tissues and its pharmacokinetics in rabbit" @default.
- W2361072064 hasPublicationYear "2006" @default.
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