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- W2361077008 abstract "Objective To develop a HPLC assay for the determination of glycyrrhetinic acid in rat plasma.Methods Analytical column was Diamonsil C18 column(4.6 mm×25 cm,5 μm) at 30 ℃ with the mobile phase consisted of methanol,water and acetic acid(86∶13.6∶0.4).The flow rate was 1.0 mL·min-1,and the UV detection was set at 250 nm.The sample size was 20 μL,and testosterone propionate was used as the internal standard.Results The linear calibration curve was obtained in the concentration range of 0.1-3.0 mg·L-1(r=0.999 9).The lower limit of qualification was 0.1 mg·L-1.The intra-day and inter-day RSD were less than 6%.Conclusion The method is simple,rapid and suitable for the determination of glycyrrhetinic acid in rat plasma and the study of pharmacokinetics." @default.
- W2361077008 created "2016-06-24" @default.
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- W2361077008 date "2011-01-01" @default.
- W2361077008 modified "2023-09-28" @default.
- W2361077008 title "Determination of glycyrrhetinic acid in rat plasma by RP-HPLC" @default.
- W2361077008 hasPublicationYear "2011" @default.
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