Matches in SemOpenAlex for { <https://semopenalex.org/work/W2361110297> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2361110297 abstract "Objective This study was designed to investigate the effect of portal collagenase administration on collagen content in cirrhotic liver and the ɑ-SMA expression induced by CCl4 subcutaneous injections in rabbits.Methods Male New Zealand rabbits were injected 50% CCl4(0.23 ml/kg)subcutaneously at gluteal region twice a week for 12 weeks to induce liver cirrhosis.The rabbits in control group administered same volumes of olive oil.After the portal delivery system(PDS)was established,33 rabbits with established liver cirrhosis were divided randomly into 2 groups.The animals in group 1(n=16)were injected 1.5 ml of 0.1% type Ⅳ collagenase saline solution through PDS.The rabbits in group 2(n=17)received the same volume of 0.9%sodium chloride as controls.The injection was conducted 5 times weekly and continued for 4 weeks.Another 30 animals which were injected with olive oil were similarly divided into group 3(n=15)and group 4(n=15)which underwent the same procedure.All the animals were sacrificed after the last injection,and the livers were removed for histologic examination and hydroxyproline detection.Also ɑ-SMA was observed by immunohistochemistry.The integral optical density and area density were calculated by an imaging analysis system.Results The expression of ɑ-SMA in the cirrhotic liver was remarkedly increased.Portal administration of collagenase significantly attenuated liver cirrhosis and decreased the hydroxyproline content,but the ɑ-SMA expression was increased markedly in liver parenchyma.Conclusions Collagenase portal administration significantly alleviated liver cirrhosis,while the ɑ-SMA expression in liver parenchyma was increased.This may attribute to the enhanced activation of hepatic stellate cells by collagenase treatment." @default.
- W2361110297 created "2016-06-24" @default.
- W2361110297 creator A5071509951 @default.
- W2361110297 date "2011-01-01" @default.
- W2361110297 modified "2023-09-25" @default.
- W2361110297 title "Effect on liver cirrhosis and the activation of hepatic stellate cells by portal collagenase administration" @default.
- W2361110297 hasPublicationYear "2011" @default.
- W2361110297 type Work @default.
- W2361110297 sameAs 2361110297 @default.
- W2361110297 citedByCount "0" @default.
- W2361110297 crossrefType "journal-article" @default.
- W2361110297 hasAuthorship W2361110297A5071509951 @default.
- W2361110297 hasConcept C102124568 @default.
- W2361110297 hasConcept C126322002 @default.
- W2361110297 hasConcept C134018914 @default.
- W2361110297 hasConcept C142724271 @default.
- W2361110297 hasConcept C176891718 @default.
- W2361110297 hasConcept C178790620 @default.
- W2361110297 hasConcept C181199279 @default.
- W2361110297 hasConcept C185592680 @default.
- W2361110297 hasConcept C196822366 @default.
- W2361110297 hasConcept C2776390293 @default.
- W2361110297 hasConcept C2777214474 @default.
- W2361110297 hasConcept C2777359374 @default.
- W2361110297 hasConcept C2777397205 @default.
- W2361110297 hasConcept C2777575235 @default.
- W2361110297 hasConcept C2778394429 @default.
- W2361110297 hasConcept C2779797417 @default.
- W2361110297 hasConcept C55493867 @default.
- W2361110297 hasConcept C71924100 @default.
- W2361110297 hasConcept C90924648 @default.
- W2361110297 hasConceptScore W2361110297C102124568 @default.
- W2361110297 hasConceptScore W2361110297C126322002 @default.
- W2361110297 hasConceptScore W2361110297C134018914 @default.
- W2361110297 hasConceptScore W2361110297C142724271 @default.
- W2361110297 hasConceptScore W2361110297C176891718 @default.
- W2361110297 hasConceptScore W2361110297C178790620 @default.
- W2361110297 hasConceptScore W2361110297C181199279 @default.
- W2361110297 hasConceptScore W2361110297C185592680 @default.
- W2361110297 hasConceptScore W2361110297C196822366 @default.
- W2361110297 hasConceptScore W2361110297C2776390293 @default.
- W2361110297 hasConceptScore W2361110297C2777214474 @default.
- W2361110297 hasConceptScore W2361110297C2777359374 @default.
- W2361110297 hasConceptScore W2361110297C2777397205 @default.
- W2361110297 hasConceptScore W2361110297C2777575235 @default.
- W2361110297 hasConceptScore W2361110297C2778394429 @default.
- W2361110297 hasConceptScore W2361110297C2779797417 @default.
- W2361110297 hasConceptScore W2361110297C55493867 @default.
- W2361110297 hasConceptScore W2361110297C71924100 @default.
- W2361110297 hasConceptScore W2361110297C90924648 @default.
- W2361110297 hasLocation W23611102971 @default.
- W2361110297 hasOpenAccess W2361110297 @default.
- W2361110297 hasPrimaryLocation W23611102971 @default.
- W2361110297 hasRelatedWork W1968142370 @default.
- W2361110297 hasRelatedWork W2123796791 @default.
- W2361110297 hasRelatedWork W2139973542 @default.
- W2361110297 hasRelatedWork W2293605037 @default.
- W2361110297 hasRelatedWork W2354690729 @default.
- W2361110297 hasRelatedWork W2357464804 @default.
- W2361110297 hasRelatedWork W2359883806 @default.
- W2361110297 hasRelatedWork W2362061263 @default.
- W2361110297 hasRelatedWork W2362659140 @default.
- W2361110297 hasRelatedWork W2364476542 @default.
- W2361110297 hasRelatedWork W2364605346 @default.
- W2361110297 hasRelatedWork W2368043280 @default.
- W2361110297 hasRelatedWork W2369029115 @default.
- W2361110297 hasRelatedWork W2370679472 @default.
- W2361110297 hasRelatedWork W2375747502 @default.
- W2361110297 hasRelatedWork W2376951567 @default.
- W2361110297 hasRelatedWork W2389076965 @default.
- W2361110297 hasRelatedWork W3031960958 @default.
- W2361110297 hasRelatedWork W3032355020 @default.
- W2361110297 hasRelatedWork W3117099773 @default.
- W2361110297 isParatext "false" @default.
- W2361110297 isRetracted "false" @default.
- W2361110297 magId "2361110297" @default.
- W2361110297 workType "article" @default.