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- W2361111583 abstract "Objectives To assess the changes of plasma levels of pro-brain natriuretic peptide(proBNP) in patients with chronic heart failure with normal ejection fraction(HFNEF) after recombinant human brain natriuretic peptide(rhBNP) treatment.Methods Fitty-ong patients with HFNEF(New York heart association functional classification Ⅲ / Ⅳ) were divided into control group(n=30,treated with routine therapy) and treatment group(n=21,treated with rhBNP for 4-7 days in addition to routine therapy).After 1 week,changes of proBNP concentrations and clinical symptoms were observed and compared between the two groups.Results After 4-7 days’ treatment,effective rate was 95.2% in treatment group and 93.3% in control group,but the difference between them was insignificant(P 0.05).Plasma concentrations of proBNP in both control group and treatment group decreased after treatment(P0.05);while plasma concentrations of proBNP in treatment group were significantly lower than those in control group [1 297.5 pg / mL vs.2 037.8 pg / mL,P 0.05].Conclusions Plasma concentrations of proBNP in patients with HFNEF decrease after treatment with rhBNP and symptoms of the patients can be improved." @default.
- W2361111583 created "2016-06-24" @default.
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- W2361111583 date "2013-01-01" @default.
- W2361111583 modified "2023-09-24" @default.
- W2361111583 title "Effect of recombinant human brain natriuretic peptide on pro-brain natriuretic peptide in patients with chronic heart failure with normal ejection fraction" @default.
- W2361111583 hasPublicationYear "2013" @default.
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