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- W2361114391 abstract "OBJECTIVE To prepare sustained-release TJ0711 hydrochloride tablets with several kinds of matrix materials and evaluate its release property in vitro.METHODS The effects of the viscosity of HPMC,amount of HPMC,stearyl alcohol,CMC-Na were studied,using release rate of drug as marker.The formulation was optimized by the orthogonal design test.RESULTS The optimized prescription: amount of HPMC K4M,stearyl alcohol and CMC-Na were 40%,20%,10%,respectively.The release rate of this drug conformed to Higuchi equation(Q=33.909t1/2-20.263,r=0.996 2) and the drug was sustained released in vitro within 12 h.CONCLUSION The formulation of TJ0711 hydrochloride sustained-release tablets is feasible." @default.
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- W2361114391 date "2012-01-01" @default.
- W2361114391 modified "2023-09-28" @default.
- W2361114391 title "Preparation of TJ0711 hydrochloride sustained release tablets and evaluation of its in vitro drug release" @default.
- W2361114391 hasPublicationYear "2012" @default.
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