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- W2361131322 abstract "Objective To investigate the role of N-methyl-D-aspartic acid receptor 2B(NR2B) and postsynaptic density 95(PSD-95) in development of vascular dementia(VaD) of rats.Methods The VaD rat model was established by permanent occlusion of bilateral common carotid arteries.One hundred and twenty-eight Wistar rats were randomly divided into sham operation group,VaD model group and memantine-treated group.The water maze test was used to test the ability of learning and memory of the rats and the changes of the expression of NR2B and PSD-95 in hippocampus were measured by immunohistochemical staining.Results The ability of learning and memory of VaD rats decreased significantly compared with the sham operation rats(P0.01).NR2B and PSD-95 had the similar expression in VaD rats,which first increased greatly(P0.01),then fell and was significantly different from that in the sham operation group(P0.01).In memantine-treated group,at 4 weeks after operation,the rats presented no statistical difference in learning and memory level and the expression of NR2B and PSD-95 as compared with the sham operation group.However,at 8,12,16 weeks after operation,the indexes mentioned above were better than those in VaD rats and still worse than those in the sham operation group(P0.05,P0.01).Conclusion NR2B and PSD-95 are involved in the development of VaD and memantine can improve recognitive function by modulating the expression of NR2B." @default.
- W2361131322 created "2016-06-24" @default.
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- W2361131322 date "2008-01-01" @default.
- W2361131322 modified "2023-09-26" @default.
- W2361131322 title "The mechanism of action of NR2B/PSD-95 in the vascular dementia rats" @default.
- W2361131322 hasPublicationYear "2008" @default.
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