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- W2361133688 abstract "Objective To observe whether insulin-like growth factor 2 (IGF-Ⅱ) possesses the activities of regulating nitric oxide (NO) levels and inducible oxide synthase (iNOS) mRNA transcriptions in mouse osteoblast-like cells. Methods Mouse osteoblastic cell line MC3T3 - E1 was selected as a cell model for examining the activities of IGF-Ⅱ. After the cells were treated with IGF-Ⅱ at different concentrations for 72 hrs, nitrate reductase method was applied for detecting the NO concentrations in the cultured cell supernatants, and semi-quantitative RT - PCR was employed for determining the levels of cellular iNOS mRNA. Results After the MC3T3-E1 cells were treated with IGF-Ⅱ at the dosage of 100 ng/mL for 72 hrs, the levels of NO in the supernatants of cell cultures and cellular iNOS mRNA were decreased significantly (P0.01). Conclusion IGF-Ⅱ at the concentration of 100 ng/mL was able to decrease NO levels and down-regulate iNOS mRNA transcription in MC3T3 - E1 cells. The down regulation of iNOS mRNA gene expression at the level of transcription in the MC3T3 - E1 cells treated with 100 ng/mL IGF-Ⅱ might be one of the mechanisms to keep low NO levels." @default.
- W2361133688 created "2016-06-24" @default.
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- W2361133688 date "2004-01-01" @default.
- W2361133688 modified "2023-09-23" @default.
- W2361133688 title "Effects of Insulin-like Growth Factor II (IGF-II) on the Inducible Nitric Oxide Synthase Gene Expression in Mouse Osteoblast-Like Cells" @default.
- W2361133688 hasPublicationYear "2004" @default.
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