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- W2361139935 abstract "AIM:The influence of EDRF on the vasoconstrictor effect of norepinephrine in rings of rat aorta has been studied. METHODS:Rings of rat aorta, with or without endothelium, were suspended in organ chambers for the measurement of contractive force and contractive speed. All experiments were performed in the presence of indomethacin (10 μmol·L -1 ) and propranolol (3 μmol·L -1 ) to prevent the production of vasoactive prostanoids and the binding of norepinephrine with beta receptor. RESULTS:In preparations with intact endothelium, methylene blue (10 μmol·L -1 ), an inhibitor of target enzyme of EDRF, and N G nitro L arginine (30 μmol·L -1 ), an inhibitor of EDRF formation, removed dose contraction curves of NE to left: the EC 30 value was decreased 7 fold and the maximal responses ratios was 1 6±0 3 and 1 7±0 4( n =10), respectively. This potentiation was similar to that observed after mechanical removal of the endothelium: a 3 fold decrease in the EC 30 value and a ratios of 1 1±0 6 and 1 1±0 4( n =9) in maximal response, respectively and the latter results may be related with a little EDRF produced by vascular smooth muscle. CONCLUSIONS:Our results showed that the norepinephrine induced contractions are also markedly modulated by EDRF produced by the endothelium and the vascular smooth muscle." @default.
- W2361139935 created "2016-06-24" @default.
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- W2361139935 date "1997-01-01" @default.
- W2361139935 modified "2023-09-25" @default.
- W2361139935 title "Effects of EDRF on the vasoconstrictor action of NE in rat aorta" @default.
- W2361139935 hasPublicationYear "1997" @default.
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