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- W2361142561 abstract "Objective To study the gene expression and role of c-myc in tumorigenesis in a double-transgenic mouse model coexpressing c-myc and SV40Tag.Method It was shown that transgenic mouse model positively coexpressing Tet-on and pTRE2-SV40Tag are prone to develop brain tumor.In this study,transgenic mice positively coexpressing Tet-on,pTRE2-SV40Tag and pTRE2-c-myc were generated by crossing the pTRE2-c-myc-expressing transgenic mice with bitransgenic mice coexpressing both Tet-on and pTRE2-SV40Tag.Brain and pancreatic tumors were induced by doxycycline(DOX) in those mice.The site and time course of the tumor development and the tumorigenesis were investigated by RT-PCR,histopathology and MRI imaging.Result The transgenic mice model coexpressing Tet-on,pTRE2-SV40Tag and pTRE2-c-myc showed the following features:(1) The mouse model was prone to develop DOX-induced tumors more frequently and rapidly in comparison with that in double-transgenic mice coexpressing Tet-on and pTRE2-SV40Tag.(2) RT-PCR results showed that c-myc and SV40Tag were expressed in the brain and pancreas and the expression was correlated with the time course. Conclusion In this bitransgenic c-myc/SVTag mouse model,tumors occur with a higher rate and within a shorter time in comparison with the single-transgenic SVTag mice,suggesting that c-myc expression is closely involved in tumorigenesis." @default.
- W2361142561 created "2016-06-24" @default.
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- W2361142561 date "2008-01-01" @default.
- W2361142561 modified "2023-09-25" @default.
- W2361142561 title "Establishment of a Tumor Model in Tet-on-Induced Double-Transgenic Mice Coexpressing c-myc and SV40Tag" @default.
- W2361142561 hasPublicationYear "2008" @default.
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