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- W2361151922 abstract "Objective By studing the expression and degradation of P27 protein in NSCLC and their correlation with clinical pathologic features and prognosis of NSCLC to elucidate the significance of expression of P27 protein its regulating mechanism and the value in the prognosis of NSCLC.Methods Immunohistochemincal detection of P27 protein in NSCLC; ubiquitin瞤roteasome detection of the P27 protein degradation in NSCLC; statistics method analysis of the relation of the expression of P27 protein to patients of postoperative survival duration.Results ①Compared with normal lung,P27 protein degradation of NSCLC increased to a greater or less extent, and was closely negatively related to the cell of P27 protein.②In 86 cases,patients with negative expression of NSCLC P27 protein accounts for 5.8%,those with positive cell rate 50% and positive cell rate 50% account for 69.8% and 24.4% respectively.③In NSCLC,P27 protein positive rate related to the survival duration and survival rate of the patients of postoperation,the mean survival duration and rate of low P27 protein expression was apparently below that of high P27 protein expression(P0.01).④Multifactor analyse of Cox model showed that expression of P27 protein was the main related factor which could affect the prognosis of NSCLC.Conclusions ①The expression of P27 protein decreased in NSCLC.②P27 protein degradation activity increased in NSCLC compared with normal lung and was negatively related to the level of P27 protein,which were of the main factors affecting P27 protein level.③Low expression of P27 protein was a marker of poor prognosis of NSCLC." @default.
- W2361151922 created "2016-06-24" @default.
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- W2361151922 date "2001-01-01" @default.
- W2361151922 modified "2023-09-25" @default.
- W2361151922 title "Expression and degradation of P27 protein in NSCLC and its correlation with prognosis" @default.
- W2361151922 hasPublicationYear "2001" @default.
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