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- W2361152400 abstract "In order to explore the oxidative damages induced by nanometer -sized Zn/Al -hydrotalcite, Hela cells were exposed to different concentrations (0, 50, 100, 200, 400, 800μg·mL-1)of the nanoparticles for 12h. After 12h exposure, the activity of superoxide dismutase (SOD)and the content of glutathione (GSH)were measured. Results showed that the activity of SOD in Hela cells decreased gradually with the increase of concentrations of nanometer -sized Zn/Al -hydrotalcite. There was no significant difference in SOD activities between the low concentrations (≤100μg·mL -1)of nanometer -sized Zn/Al -hydrotalcite and the control (p 0.05). But significant differences were found between the high concentrations (≥200μg·mL-1)of nanometer-sized Zn/Al-hydrotalcite and the control (p0.01). The content of GSH in Hela cells also decreased gradually with the increase of concentrations of nanometer -sized Zn/Al-hydrotalcite. There was no significant difference in GSH contents between the low concentrations(≤50μg·mL-1)of nanometer-sized Zn/Al-hydrotalcite and the control (p 0.05). But significant differences were found between the high concentrations (≥100μg·mL -1)of nanometer-sized Zn/Al-hydrotalcite and the control(p0.05 or p0.01). In this experiment, there were certain dose-effect relationships between various concentrations of the nanometer-sized Zn/Al -hydrotalcite and the SOD activity and GSH content in Hela cells. The results indicated that high concentrations of nanometer-sized Zn/Al -hydrotalcite could cause oxidative damage to Hela cells, and low concentrations of nanometer-sized Zn/Al-hydrotalcite were biocompatible." @default.
- W2361152400 created "2016-06-24" @default.
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- W2361152400 date "2009-01-01" @default.
- W2361152400 modified "2023-09-27" @default.
- W2361152400 title "Oxidative Stress Induced by Nanometer-Sized Zn/Al-Hydrotalcite Particles in Hela Cells" @default.
- W2361152400 hasPublicationYear "2009" @default.
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