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- W2361173635 abstract "OBJECTIVE To determine the potential anti-inflammatory and analgesic activities of saponins from D. zingiberensis C. H. Wright and diosgenin derivative on xylene-induced acute ear edema in mice. METHODS 3beta-2-acetoxy-benzoyl-diosgenin ester (ABDE) was synthesized by acylation of aspirin through two-step of reaction. The analgesic activities of ABDE and saponins were investigated through acetic acid-induced writhing response of the mice. The anti-inflammatory effects of saponins and ABDE were observed on the xylene-induced swelling ears of the mice. RESULTS The structure of ABDE was confirmed by 1H-NMR and ESI-MS. ABDE had significantly higher anti-inflammatory and analgesic activities than the comparison drug. The saponins demonstrated 7.92% and 14.51% anti-inflammatory activities at the dose of 126 mg/kg and 252 mg/kg, respectively, and 15.38% and 26.15% analgesic activities at the dose of 126 mg/kg and 252 mg/kg, respectively. CONCLUSION The saponins of D. zingiberensis C. H. Wright possess acute nonspecific anti-inflammatory and analgesic effects. The anti-inflammatory and analgesic effects of ABDE are equivalent to aspirin." @default.
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- W2361173635 date "2011-07-01" @default.
- W2361173635 modified "2023-09-27" @default.
- W2361173635 title "[Anti-inflammatory and analgesic effects of saponins from D. zingiberensis C. H. Wright and diosgenin derivative on mice]." @default.
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