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- W2361180978 abstract "Objective:To study the effects of occlusal support loss on the concentration of amino acid neurotransmitters in hippocampus of rats with impaired cognitive function.Methods:The cognitive function of 35 Wistar rats was examined by the one trial passive avoidance response,12 rats with normal cognitive function and 11 rats with impaired cognitive function were selected.Then the 23 rats were randomly divided into four groups:control group with normal cognitive function(group A-1),unilateral molars extraction group with normal cognitive function(group A-2),control group with impaired cognitive function(group B-1) and unilateral molars extraction group with impaired cognitive function(group B-2).Six weeks after the molars extraction,all rats were decapitated and the hippocampi were dissected to measure the amino acid neurotransmitters concentration.Results:Compared with the group A-1,the contents of gama-aminobutyric and taurine in group B-1 increased significantly(P 0.05);Compared with the group A-1,in group B-2 the contents of glutamate,gama-aminobutyric,glycine and taurine all increased significantly(P 0.01,P 0.001,P 0.05,P 0.01);Compared with the group A-2,in group B-2 the contents of glutamate,gama-aminobutyric were both increased significantly(P 0.05,P 0.01);Compared with the group B-1,in group B-2 the contents of gama-aminobutyric were increased significantly(P 0.05).Conclusion:Within the limitation of this study,amino acid neurotransmitters contents in hippocampus of rats with impaired cognitive function plus occlusal support loss were significantly higher than that in other groups." @default.
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- W2361180978 date "2008-01-01" @default.
- W2361180978 modified "2023-09-23" @default.
- W2361180978 title "Effects of occlusal support loss on the concentration of amino acid neurotransmitters in hippocampus of rats with impaired cognitive function" @default.
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