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- W2361182023 abstract "Objective To investigate the protective effect of tetramethylpyrazine(TMP) to acute lung injury in rats induced by oleic acid and its possible mechanisms.Methods Rat models of acute lung injury induced by oleic acid(OA) were used.Thirty six Sprague-Dawley male rats were randomly divided into 3 groups: Control group,OA group and TMP group.All rats in each group were killed at 1h and 4h after oleic acid infusion or physiological saline infusion.Morphological changes of lung tissues and liver tissues were observed under light microscope.The content of Malonaldehyde(MDA) and the activity of superoxide dismutase(SOD) were detected in each group.Results Morphological changes of lung tissues and liver tissues showed that pulmonary inflammation was relieved in TMP group compared with that of OA group.The content of MDA increased(P0.05) and the activity of SOD decreased(P0.05) progressively in OA group and in TMP group with the time prolonging,but the change was not obvious in control group(P0.05).The content of MDA in TMP group were lower than those in OA group at the same time(P0.05),but higher than that of the control group(P0.05).The activity of SOD in TMP group were higher than those in OA group at the same time(P0.05),but lower than that of the control group(P0.05).Conclusion Tetramethylpyrazine could antagonize acute lung injury induced by OA,which is probably through decreasing the level of free radical in rats." @default.
- W2361182023 created "2016-06-24" @default.
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- W2361182023 date "2013-01-01" @default.
- W2361182023 modified "2023-09-24" @default.
- W2361182023 title "Antagonistic mechanisms of tetramethylpyrazine to acute lung injury in rats induced by oleic acid" @default.
- W2361182023 hasPublicationYear "2013" @default.
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