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- W2361205904 abstract "Objective:To investigate the infiltration of CD45RO+ T cells and CD68+ cells in the lesions of non-neoplastic epithelial disorder and in vulva cancer.Methods:The infiltration of CD45RO+ T cells and CD68+ cells was detected with S-P immunohistochemistry in the lesions of 20 non-neoplastic epithelial disorders,including vulvar squamous cell hyperplasia(SH) and vulvar lichen sclerosus(LS)) and vulvar cancer,respectively.The vulvar skins from 10 healthy individuals were selected as the control.Results:The infiltration of CD45RO+ T cells and CD68+ cells in healthy vulvar skin was very low and significantly lower than that in SH,LS and vulvar cancer(P0.05).The infiltration of such cells in later stage of SH was significantly higher than in early stage(P0.05),and so did in well/moderately differentiated vulvar cancer than that in poorly differentiated ones(P0.05).The infiltration of CD45RO+ T cells was highest in well/moderately differentiated vulvar cancer,and then in later stage of LS(P0.05),whereas the infiltration of CD68+ cells was highest in well/moderately differentiated vulvar cancer and later stage of LS(P0.05).The number of both cells were significantly higher than that in SH,poorly vulvar cancer and early stage of LS(P0.05),with no significant difference among SH,poorly vulvar cancer and early stage of LS(P0.05).The infiltration of CD68+ cells was shown in a positive correlation with CD45RO+ T cells in the different lesion of vulva,the correlation coefficient was 0.742(P0.05).The CD68 positive cells often appeared around the CD45RO+ T cells in the lesion and most occurred at the superficial layer.Conclusion:CD45RO+ T cells and CD68+ cells take parts in the immune reaction in the skin,and act as immunological regulation during development of non-neoplastic epithelial disorders and cancer of the vulva." @default.
- W2361205904 created "2016-06-24" @default.
- W2361205904 creator A5012292041 @default.
- W2361205904 date "2008-01-01" @default.
- W2361205904 modified "2023-09-23" @default.
- W2361205904 title "Infiltration of CD45RO~+ T cells and CD68~+ cells in non-neoplastic epithelial disorders and vulva cancer" @default.
- W2361205904 hasPublicationYear "2008" @default.
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