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- W2361235583 abstract "To study the joint effects of exercise and soybean isoflavone on ovariectomised rats osteoporo-sis,60 three-month-old female Sprangue-Dawley(SD) rats were randomly divided into 5 groups averagely accord-ing to weight,including sham operation group(SHAM,n=12),ovariectomised group(OVX,n=12),isoflavone treated group(ISO,n=12),combined group of exercise plus isoflavone(ISO+E,n=12) and estrogen treated group(E2,n=12).Rats in each group were kept in a separate cage,Except for the SHAM group,all groups of rats received celiac operation to have their ovaries removed.ISO group fed on isoflavone 30 mg/kg body weight eve-ryday;ISO+E group fed on isoflavone 30 mg /kg body weight everyday and ran on treadmill 5 times every week;E2 group fed on estrogen 0.1mg/kg body weight everyday.All rats drank water freely,and were fed on standard food.The experiment lasted for three months.After that,all rats were killed by cut femoral artery,stripping uterus and weighing,stripping femur,sem observation of top of the femur.The results are as follows.The uterus index: Compared with SHAM and E2 groups,OVX group uterus index significantly decreased(P 0.01),OVX group,ISO +E group and ISO group uterus index have significantly raised,there were significant differences in ISO + E group and OVX group(P 0.05).Scanning electron microscopy: there is obvious difference between OVX group femoral cancellous trabeculae and that of SHAM groups and E2 group,OVX groups femoral head bone trabeculae structure is irregular,trabeculae mostly were absorption,destruction,the connection between the bone trabeculae was disappeared,the gap between trabeculae increased obviously,trabecular became thin,perforation,fracture,the structural integrity was destruction,the numbers of bone trabeculae reduced.ISO +E,SHAM and E2 group structure is similar,have more trabeculae in number,trabeculae is thicker,clearance is smaller and complete structure.Therefore,exercise combined with isoflavone can inhibit bone microscopic structure degradation,im-prove bone microstructure.The joint effects can resist osteoporosis." @default.
- W2361235583 created "2016-06-24" @default.
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- W2361235583 date "2011-01-01" @default.
- W2361235583 modified "2023-09-26" @default.
- W2361235583 title "The influence of soybean isoflavone combined with exercise on ovariectomised rats osteoporosis" @default.
- W2361235583 hasPublicationYear "2011" @default.
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