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- W2361246225 abstract "Objective To evaluate the efficacy of finished-product amniotic membrane and anterior lens capsule implantation in phacoemulsification combined with trabeculectomy in rabbits.Methods Twenty-four New Zealand white rabbits were randomly divided into group A,B and C,8 cases in each group.The finished-product amniotic membrane and anterior lens capsule were respectively implanted under the scleral flap in phacoemulsification combined with trabeculectomy in group A and group B,while only phacoemulsification combined with trabeculectomy in group C.The anterior chamber inflammation reaction and type of filtering bleb were observed under the slit lamp,intraocular pressure ( IOP) was measured at postoperative 1 day,7 days,14 days,28 days,and pathological changes in filter corridor were also observed under the photon microscope.Results The postoperative IOP in group A,B and C decreased obviously,there were statistical differences among the three groups at postoperative 7 days,14 days,21 days( P 0.05) .Whilecompared group A with group B,finished-product amniotic membrane could effectively depress IOP,which at postoperative 7 days,14 days,21 days in group A were ( 7.17±0.22) mmHg ( 1 kPa = 7.5 mmHg) ,( 7.54±0.47) mmHg and ( 11.81±0.74) mmHg,in group B were ( 7.79±0.16) mmHg,( 8.76±0.81) mmHg and ( 14.03±0.25) mmHg,there were statistical differences between two groups( all P 0.05) .While anterior chamber inflammation reaction and filtering bleb type at postoperative 1 day,7 days,14 days,21 days among group A,B and C,group A and B had more functional filtering bleb and serious anterior chamber inflammation reaction,but the difference was not statistically significant ( P 0.05 ) .Histopathology examination showed that the passage of humor outflow kept open at early stage after surgery in all groups.The maintenance of functional filtering bleb associated with implants.At postoperative 28 days,the passage of humor outflow opened completely in group A and B,and there were less fibroblasts in group A,but few inflammatory cells infiltrated,the edge of anterior lens capsule became dull,there were still no lymphocytes in group B,the filtering trace was completely blocked by the scar tissue in group C.Conclusion Application of finished-product amniotic membrane and anterior lens capsule in phacoemulsification combined with trabeculectomy may safely and effectively depress IOP,inhibit or relieve the growth of fibroblasts,and improve the success rate of surgery." @default.
- W2361246225 created "2016-06-24" @default.
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- W2361246225 date "2013-01-01" @default.
- W2361246225 modified "2023-09-23" @default.
- W2361246225 title "Application of finished-product amniotic membrane and anterior lens capsule in phacoemulsification combined with trabeculectomy in rabbits" @default.
- W2361246225 hasPublicationYear "2013" @default.
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